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Vitamin D Insufficiency and Abnormal Hemoglobin A1c in Black and White Older Persons

Identifieur interne : 000850 ( Main/Exploration ); précédent : 000849; suivant : 000851

Vitamin D Insufficiency and Abnormal Hemoglobin A1c in Black and White Older Persons

Auteurs : Jatupol Kositsawat ; George A. Kuchel ; Janet A. Tooze ; Denise K. Houston ; Jane A. Cauley ; Stephen B. Kritchevsky ; Elsa S. Strotmeyer ; Alka M. Kanaya ; Tamara B. Harris ; Karen C. Johnson ; Lisa C. Barry

Source :

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences [ 1079-5006 ] ; 2014.

RBID : PMC:4375414

Descripteurs français

KwdFr :
- Afro-Américains (), Carence en vitamine D (), Carence en vitamine D (diagnostic), Carence en vitamine D (ethnologie), Carence en vitamine D (sang), Diabète de type 2 (), Diabète de type 2 (diagnostic), Diabète de type 2 (ethnologie), Diabète de type 2 (sang), Femelle, Humains, Hémoglobine A glycosylée (métabolisme), Indice de masse corporelle, Marqueurs biologiques (sang), Medicare (USA) (), Mâle, Pennsylvanie (épidémiologie), Population d'origine européenne (), Sensibilité et spécificité, Sujet âgé, Tennessee (épidémiologie), Valeur prédictive des tests, Vie autonome, Vitamine D (analogues et dérivés), Vitamine D (sang), États-Unis d'Amérique, Études longitudinales.
MESH :
- analogues et dérivés : Vitamine D.
- diagnostic : Carence en vitamine D, Diabète de type 2.
- ethnologie : Carence en vitamine D, Diabète de type 2.
- métabolisme : Hémoglobine A glycosylée.
- sang : Carence en vitamine D, Diabète de type 2, Marqueurs biologiques, Vitamine D.
- épidémiologie : Pennsylvanie, Tennessee.
- Afro-Américains, Carence en vitamine D, Diabète de type 2, Femelle, Humains, Indice de masse corporelle, Medicare (USA), Mâle, Population d'origine européenne, Sensibilité et spécificité, Sujet âgé, Valeur prédictive des tests, Vie autonome, États-Unis d'Amérique, Études longitudinales.

English descriptors

KwdEn :
- African Americans (statistics & numerical data), Aged, Biomarkers (blood), Body Mass Index, Diabetes Mellitus, Type 2 (blood), Diabetes Mellitus, Type 2 (complications), Diabetes Mellitus, Type 2 (diagnosis), Diabetes Mellitus, Type 2 (ethnology), European Continental Ancestry Group (statistics & numerical data), Female, Hemoglobin A, Glycosylated (metabolism), Humans, Independent Living, Longitudinal Studies, Male, Medicare (statistics & numerical data), Pennsylvania (epidemiology), Predictive Value of Tests, Sensitivity and Specificity, Tennessee (epidemiology), United States, Vitamin D (analogs & derivatives), Vitamin D (blood), Vitamin D Deficiency (blood), Vitamin D Deficiency (complications), Vitamin D Deficiency (diagnosis), Vitamin D Deficiency (ethnology).
MESH :
- chemical , analogs & derivatives : Vitamin D.
- chemical , blood : Biomarkers, Vitamin D.
- geographic , epidemiology : Pennsylvania, Tennessee.
- blood : Diabetes Mellitus, Type 2, Vitamin D Deficiency.
- complications : Diabetes Mellitus, Type 2, Vitamin D Deficiency.
- diagnosis : Diabetes Mellitus, Type 2, Vitamin D Deficiency.
- ethnology : Diabetes Mellitus, Type 2, Vitamin D Deficiency.
- chemical , metabolism : Hemoglobin A, Glycosylated.
- statistics & numerical data : African Americans, European Continental Ancestry Group, Medicare.
- Aged, Body Mass Index, Female, Humans, Independent Living, Longitudinal Studies, Male, Predictive Value of Tests, Sensitivity and Specificity, United States.

Abstract

Background.

Although vitamin D has been mechanistically linked to insulin secretion and sensitivity, it remains unclear whether low 25-hydroxyvitamin D levels confer an increased risk of impaired glucose metabolism. We evaluated the relationship between vitamin D insufficiency (25-hydroxyvitamin D < 20ng/mL) and abnormal hemoglobin A1c (A1c) (≥6.5%) in community-dwelling older persons and examined whether this relationship differed according to race.

Methods.

Participants were 2,193 persons of age 70–79 years at Year 1 (52% women; 37% black) in the Health, Aging, and Body Composition study who had clinic visits at Years 2 and 4. Logistic regression analyses, adjusted for potential confounders, were used to evaluate the association between vitamin D insufficiency and abnormal A1c 2 years later. Interaction of race and vitamin D insufficiency was tested.

Results.

A total of 665 (30%) and 301 (14%) of the participants had vitamin D insufficiency at Year 2 and abnormal A1c at Year 4, respectively. After controlling for demographics, other potential confounders, and diabetes status at Year 4 (n = 477 diabetics), we found that vitamin D insufficiency was associated with an increased likelihood of having abnormal A1c (odds ratio = 1.56; 95% CI: 1.03–2.37). We also found that this relationship persisted among the 1,765 participants without diabetes in Year 2 (odds ratio = 2.33; 95% CI: 1.00–5.40). Findings did not differ by race.

Conclusions.

Vitamin D insufficiency was associated with abnormal A1c levels among black and white older persons independent of diabetes status. Future studies are needed to establish the temporal relationship between vitamin D and A1c in diverse samples of older persons.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375414

DOI: 10.1093/gerona/glu122
PubMed: 25112493
PubMed Central: 4375414

Affiliations:

Le document en format XML

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<term>Aged</term>
<term>Biomarkers (blood)</term>
<term>Body Mass Index</term>
<term>Diabetes Mellitus, Type 2 (blood)</term>
<term>Diabetes Mellitus, Type 2 (complications)</term>
<term>Diabetes Mellitus, Type 2 (diagnosis)</term>
<term>Diabetes Mellitus, Type 2 (ethnology)</term>
<term>European Continental Ancestry Group (statistics & numerical data)</term>
<term>Female</term>
<term>Hemoglobin A, Glycosylated (metabolism)</term>
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<term>Independent Living</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Medicare (statistics & numerical data)</term>
<term>Pennsylvania (epidemiology)</term>
<term>Predictive Value of Tests</term>
<term>Sensitivity and Specificity</term>
<term>Tennessee (epidemiology)</term>
<term>United States</term>
<term>Vitamin D (analogs & derivatives)</term>
<term>Vitamin D (blood)</term>
<term>Vitamin D Deficiency (blood)</term>
<term>Vitamin D Deficiency (complications)</term>
<term>Vitamin D Deficiency (diagnosis)</term>
<term>Vitamin D Deficiency (ethnology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Afro-Américains ()</term>
<term>Carence en vitamine D ()</term>
<term>Carence en vitamine D (diagnostic)</term>
<term>Carence en vitamine D (ethnologie)</term>
<term>Carence en vitamine D (sang)</term>
<term>Diabète de type 2 ()</term>
<term>Diabète de type 2 (diagnostic)</term>
<term>Diabète de type 2 (ethnologie)</term>
<term>Diabète de type 2 (sang)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémoglobine A glycosylée (métabolisme)</term>
<term>Indice de masse corporelle</term>
<term>Marqueurs biologiques (sang)</term>
<term>Medicare (USA) ()</term>
<term>Mâle</term>
<term>Pennsylvanie (épidémiologie)</term>
<term>Population d'origine européenne ()</term>
<term>Sensibilité et spécificité</term>
<term>Sujet âgé</term>
<term>Tennessee (épidémiologie)</term>
<term>Valeur prédictive des tests</term>
<term>Vie autonome</term>
<term>Vitamine D (analogues et dérivés)</term>
<term>Vitamine D (sang)</term>
<term>États-Unis d'Amérique</term>
<term>Études longitudinales</term>
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<term>Vitamin D</term>
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<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Vitamine D</term>
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<term>Vitamin D Deficiency</term>
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<term>Vitamin D Deficiency</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Diabetes Mellitus, Type 2</term>
<term>Vitamin D Deficiency</term>
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<term>Diabète de type 2</term>
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<keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Carence en vitamine D</term>
<term>Diabète de type 2</term>
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<keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Diabetes Mellitus, Type 2</term>
<term>Vitamin D Deficiency</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Hémoglobine A glycosylée</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Carence en vitamine D</term>
<term>Diabète de type 2</term>
<term>Marqueurs biologiques</term>
<term>Vitamine D</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>African Americans</term>
<term>European Continental Ancestry Group</term>
<term>Medicare</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Pennsylvanie</term>
<term>Tennessee</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Body Mass Index</term>
<term>Female</term>
<term>Humans</term>
<term>Independent Living</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Predictive Value of Tests</term>
<term>Sensitivity and Specificity</term>
<term>United States</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Afro-Américains</term>
<term>Carence en vitamine D</term>
<term>Diabète de type 2</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Medicare (USA)</term>
<term>Mâle</term>
<term>Population d'origine européenne</term>
<term>Sensibilité et spécificité</term>
<term>Sujet âgé</term>
<term>Valeur prédictive des tests</term>
<term>Vie autonome</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background.</title>
<p>Although vitamin D has been mechanistically linked to insulin secretion and sensitivity, it remains unclear whether low 25-hydroxyvitamin D levels confer an increased risk of impaired glucose metabolism. We evaluated the relationship between vitamin D insufficiency (25-hydroxyvitamin D < 20ng/mL) and abnormal hemoglobin A1c (A1c) (≥6.5%) in community-dwelling older persons and examined whether this relationship differed according to race.</p>
</sec>
<sec><title>Methods.</title>
<p>Participants were 2,193 persons of age 70–79 years at Year 1 (52% women; 37% black) in the Health, Aging, and Body Composition study who had clinic visits at Years 2 and 4. Logistic regression analyses, adjusted for potential confounders, were used to evaluate the association between vitamin D insufficiency and abnormal A1c 2 years later. Interaction of race and vitamin D insufficiency was tested.</p>
</sec>
<sec><title>Results.</title>
<p>A total of 665 (30%) and 301 (14%) of the participants had vitamin D insufficiency at Year 2 and abnormal A1c at Year 4, respectively. After controlling for demographics, other potential confounders, and diabetes status at Year 4 (<italic>n</italic>
 = 477 diabetics), we found that vitamin D insufficiency was associated with an increased likelihood of having abnormal A1c (odds ratio = 1.56; 95% CI: 1.03–2.37). We also found that this relationship persisted among the 1,765 participants without diabetes in Year 2 (odds ratio = 2.33; 95% CI: 1.00–5.40). Findings did not differ by race.</p>
</sec>
<sec><title>Conclusions.</title>
<p>Vitamin D insufficiency was associated with abnormal A1c levels among black and white older persons independent of diabetes status. Future studies are needed to establish the temporal relationship between vitamin D and A1c in diverse samples of older persons.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Barry, Lisa C" sort="Barry, Lisa C" uniqKey="Barry L" first="Lisa C." last="Barry">Lisa C. Barry</name>
<name sortKey="Cauley, Jane A" sort="Cauley, Jane A" uniqKey="Cauley J" first="Jane A." last="Cauley">Jane A. Cauley</name>
<name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<name sortKey="Houston, Denise K" sort="Houston, Denise K" uniqKey="Houston D" first="Denise K." last="Houston">Denise K. Houston</name>
<name sortKey="Johnson, Karen C" sort="Johnson, Karen C" uniqKey="Johnson K" first="Karen C." last="Johnson">Karen C. Johnson</name>
<name sortKey="Kanaya, Alka M" sort="Kanaya, Alka M" uniqKey="Kanaya A" first="Alka M." last="Kanaya">Alka M. Kanaya</name>
<name sortKey="Kositsawat, Jatupol" sort="Kositsawat, Jatupol" uniqKey="Kositsawat J" first="Jatupol" last="Kositsawat">Jatupol Kositsawat</name>
<name sortKey="Kritchevsky, Stephen B" sort="Kritchevsky, Stephen B" uniqKey="Kritchevsky S" first="Stephen B." last="Kritchevsky">Stephen B. Kritchevsky</name>
<name sortKey="Kuchel, George A" sort="Kuchel, George A" uniqKey="Kuchel G" first="George A." last="Kuchel">George A. Kuchel</name>
<name sortKey="Strotmeyer, Elsa S" sort="Strotmeyer, Elsa S" uniqKey="Strotmeyer E" first="Elsa S." last="Strotmeyer">Elsa S. Strotmeyer</name>
<name sortKey="Tooze, Janet A" sort="Tooze, Janet A" uniqKey="Tooze J" first="Janet A." last="Tooze">Janet A. Tooze</name>
</noCountry>
</tree>
</affiliations>
</record>

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{{Explor lien
   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4375414
   |texte=   Vitamin D Insufficiency and Abnormal Hemoglobin A1c in Black and White Older Persons
}}

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Serveur d'exploration sur Pittsburgh

Vitamin D Insufficiency and Abnormal Hemoglobin A1c in Black and White Older Persons

Vitamin D Insufficiency and Abnormal Hemoglobin A1c in Black and White Older Persons

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English descriptors

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur Pittsburgh
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.